Good question. I've always found Burrough's Interzone imagery deeply vivid and relevant
From memory, his conception of it originated from a Yage/ayahuasca experience (that he documented in letters to ginsberg, released as the Yage Letters) in which he saw, in a murky and intense hellish vision, a vast futuristic city in which the entire of humankind lived, and all of the potentials of humanity exploding in all their ferocity - in ecstasy and in nightmarish murder - every imaginable potential being milked and exploited and expanded - everything from the most ecstatic of drug-fuelled orgies to droves of people clawing and gnashing eachother to death in the streets.
It's hard to say what he really meant by that but somehow it has stuck with me for many years, having first read naked lunch at 14. Just an image of the brutal, raw, intense reality of our humanness in full force. Like a trans-dimensional sphere of the source of what it means to be human - that you can visit in dreams.
Jodorowsky has similiar themes in his films obviously (Holy Mountain, El Topo etc), and I've always liked how, when people would ask him why there was so much senseless violence in his films, he would answer because violence was so much a part of our humanity and the truth of what he referred to it as 'the force of life'. I like that phrase very much, 'the force of life'.
In hindsight, on such a thing as ayahuasca which I have experienced on a few occasions - you tend to have visions, wild lucid experiences, of things which personally encapsulate your total vision of what life is all about. For Burroughs - a true hero of human evolution in my books - he saw Human Potential in it's chaos and it's possibility. Although Heroin remained his chief vice and inspiration throughout his life, it was the Ayahuasca and those visions which inspired most of his later creative work, in my opinion.