that's interesting that.Modern manga tends to be very open wrt panel layouts. Diagonals, overlaps, big splashes, dispensing with panels completely. Its relatively unusual to see consistent use of the grid.
Its difficult to overstate the influence of this and Moebius' other 70's and 80's sci fi work. There were several very important films which owe him a direct debt (such as Star Wars), then there's Neuromancer, and of course he had a huge impact on the manga world and his influence is visible in the work of top tier creators like Jiro Taniguchi, Miyazaki and Katsuhiro Otomo, who were all quite open about their admiration for his work. You could make a very good argument that the Incal is amongst a small suite of creations that had more impact on late 20th century science fiction than almost anything else.John DiFool is based upon The Fool from tarot with his name being a pun upon "John, the Fool". Animah's name is based on the Jungian concept of the anima, the feminine part of every male's psyche, as well in Latin "anima" means "psyche". The series has no taboos, an attitude towards sex, violence and general social stigmas that may be avoided in more conventional comics. They include Black-and-white dualism or the conflict between good and evil, mystical symbolism, archetypes, metaphysics, tarot and other influences. In the story there's often a conflict between life or nature and dead technology (even uniformity and diversity), as "glasses enable you to see, that's technology. But happiness is not that, it's not your glasses. It's what you are able to see.