I don't understand this, orthogonal to what?
Orthogonal to the notion of artist. The sampler and sampling as a whole is unethical in reference to the individual artist.
Of course thats why we find it so compelling, because it mirrors capitals mining of dead labour to dominate living labour. Think about jungle. a music nearly almost of made of detritus of the past in this strange, posthuman machinic way. But most of it's component ingredients are in a sense nothing but human.
Autotune requires artistic craft not technical craft.