i think the possibilities are really endless depending on 2 things
-the abilities of the "real instrument" players , their willingness to not get stuck on one jam, or to do the opposite and let a groove ride depending on the feel . their ability to switch 'genres' , tempos, poly rhythm patterns without flinching. i think they'd need some jazz chops to really make it work
and- the selection and mixing abilities of the dj . some djs dont have the arsenal of music at their disposal to really be able to freak out alongside some openminded musicians, they might like to but its just not in their crates , literal or serato.. and of course if the skills arent there then its gonna be impossible to flex on a mix from genre to genre
quick anecdote. me and a fellow drummer friend have been jamming for years mostly on drumset and auxiliary drums, recently we started messing around with keys on old casio keyboards an wahtnot . but one time a friend of mine who djs, mostly jungle, but had a few other things in his crate, came over with the intent to combine our forces. this is a kid who i know we have musical tastes in common with , but for some reason he had no flow with us , kinda just dropped beats on top of what we were playing without regard to what we were playing, did a few loud scratch things but didnt really try to have any kind of musical conversation with us
i guess thats what you need. people who are able to have a musical conversation, without interrupting eachother, an open flow of ideas . you have to be able to sit back for a second and listen to the other people, listen to what theyre doing and how it relates to what you're doing and then put your 2 cents in
also, holy first post batman