Wuhan Killer Sneeze (thanks Tea)

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mixed_biscuits

mixed_biscuits

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Mr. Tea said:
Has this happened with any of the many viral vaccines we've been using routinely for decades?
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Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

concern for an inappropriate response among persons vaccinated with a SARS-CoV vaccine emanated from experiences with coronavirus infections and disease in animals that included enhanced disease among infected animals vaccinated earlier with a coronavirus vaccine [31]. Feline infectious peritonitis coronavirus (FIPV) is a well-known example of antibody-mediated enhanced uptake of virus in macrophages that disseminate and increase virus quantities that lead to enhanced disease [31], [45]. Antigen-antibody complex formation with complement activation can also occur in that infection and some other coronavirus infections in animals. Thus, concern for safety of administering SARS-CoV vaccines to humans became an early concern in vaccine development.
 
Murphy

Murphy

cat malogen
Exactly.....caution

Conclusions​

These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.
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mixed_biscuits

mixed_biscuits

_________________________
Yeah, I wouldn't characterise our response as one demonstrating a great deal of 'caution': we're second most advanced in vaccination rollout and everything is done sloppily under unusual emergency legislation with no-one taking responsibility for any ill effects.
 
version

version

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Mr. Tea said:
Except maybe Peter Thiel, obviously.
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co-vampire.jpg
 
Leo

Leo

Well-known member
mixed_biscuits said:
I think it's a minimalist assertion that there is no evidence for it with the unstated caveat that only long-term data would provide any evidence.

A bit like saying, 'There is no current evidence that standing in the motorway is a risk' just because the articulated lorry hasn't hit me yet.
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not really. everyone knows there's tons of risk in standing in a motorway, and lots of evidence of that risk.

and of course, long-term data could prove things we don't know now, is anyone actually arguing against that? but every decision in life is a weighing of risk and reward. you don't have to get vaccinated. roll the dice, take yr chances.
 
Leo

Leo

Well-known member
mixed_biscuits said:
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

concern for an inappropriate response among persons vaccinated with a SARS-CoV vaccine emanated from experiences with coronavirus infections and disease in animals that included enhanced disease among infected animals vaccinated earlier with a coronavirus vaccine [31]. Feline infectious peritonitis coronavirus (FIPV) is a well-known example of antibody-mediated enhanced uptake of virus in macrophages that disseminate and increase virus quantities that lead to enhanced disease [31], [45]. Antigen-antibody complex formation with complement activation can also occur in that infection and some other coronavirus infections in animals. Thus, concern for safety of administering SARS-CoV vaccines to humans became an early concern in vaccine development.
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this is from 2012. has anything changed in nearly a decade?
 
Mr. Tea

Mr. Tea

Let's Talk About Ceps
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