I feel there is still a lot of scope for new ways of making music, especially in live performance, rhythm, micro-tonal , audio / visual and algorithmic stuff. I think it may have made things like granular synthesis more ubiquitous in modern sound design, I hear it all the time in movies, TV etc (Devs for example) . But it isn't accessible enough to create any real shifts or changes in how music is made imo.
You could draw comparisons to people like Chris carter making his own sound generators or people messing with huge modular racks. I think it's very rare you have someone willing to spend the time working at such a low-level who also can put the time in to create decent creative output.
Max/msp working with live was kind of addressing this in a way I think because it allowed people to get access to the patches being made but it's still a bit clunky for any end user who isn't used to max.
I spent years messing with it, made this algorithmic synth that uses cellular automata and granular synthesis to make weird noises. Once I finished that project I pretty much never opened it again, just takes way too long to get anything done.