my short-take, message board answer is yes, but only in the broadest sense
something on the order of an applied version of Nietzsche's eternal return (which I don't claim to understand perfectly) - time is infinite, humans finite
further, basic human motivations - survival, followed by meaning - remain unchanged, so some kind of repetition is inevitable
what I understand (again, imperfectly) Deleuze to ultimately mean by "difference" is that only universal constant is change (or proactively, becoming)
in other words, a fancier, more mystical (i.e. Deleuzian) way of saying you can never enter the same river twice, as per Heraclitus
as neither you, nor the river, nor the relationship between the two will be the same