Transcranial magnetic stimulation of the visual cortex
induces somatotopically organized qualia
in blind subjects
Ron Kupers*†‡, Arnaud Fumal§, Alain Maertens de Noordhout§, Albert Gjedde†, Jean Schoenen§, and Maurice Ptito†¶
*Department of Surgical Pathophysiology and Positron Emission Tomography Unit, Rigshosptitalet, DK-2100 Copenhagen, Denmark; †Positron Emission
Tomography Center, Aarhus University, DK-8000 Aarhus, Denmark; §Department of Neurology, Centre Hospitalier Re ́gional Citadelle Hospital,
4000 Lie`ge, Belgium; and ¶Ecole d’Optome ́trie, Universite ́ de Montre ́al, Montreal, QC, Canada H3C 3J7
Edited by Leslie G. Ungerleider, National Institutes of Health, Bethesda, MD, and approved June 23, 2006 (received for review April 10, 2006)
After loss of a particular sensory channel, the deprived cortex can
be activated by inputs from other sensory modalities. It is not
known whether activation of the rewired cortex evokes subjective
experiences characteristic of that cortex or consistent with the
rerouted sensory information. In a previous study, blind subjects
were trained to perform visual tasks with a tongue display unit, a
sensory substitution device that translates visual displays into
electrotactile tongue stimulation. This cross-modal sensory stimu-
lation activated their visual cortices. We now extend this finding by
using transcranial magnetic stimulation to examine the perceptual
correlates of training-induced plastic responses. We find that blind
subjects proficient with the use of the tongue display unit report
somatopically organized tactile sensations that are referred to the
tongue when transcranial magnetic stimulation is applied over the
occipital cortex. No such sensations were evoked in trained, blind-
folded, seeing control subjects who performed the sensory sub-
stitution task equally well. These data show that the perceptual
correlate of activity in a given cortical area reflects the character-
istics of its novel sensory input source.
blindness cross-modal plasticity rewiring sensation vision
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