Sure I was being flippant, but my original points were fairly flippant too so it seemed to follow. My thought process was as below.
You asked if modern technology implied a kind of loss... and I replied to say that every step forward leaves something behind... I was trying to say that with every path taken there is another path not taken and so any development necessarily involves some loss and some gain, so, in terms of deciding - as a society - whether or not to move forward with some technology, the question should not be "is something lost?" (cos something is always lost) but rather "Will we lose more than we gain?" But then I thought that, regardless of the answer, in the world we live in it tends to be that if it is possible to do something, then someone will - even if the first person decides that nuclear war or genetic engineering or time travel is too dangerous, someone else will find out how and then someone else and they will all face that dilemma and eventually it will get created even so.
However I was sort of mixing up two things - so in fact, your original question about examining how much we have lost with a particular technology is something worth thinking about and, yeah, considering how we, personally and as a society, react to the losses. There are other reasons to consider this beyond deciding whether to use them.
So... what do you think we have lost?