The cannabis debate

[luka]

Similar thing happened to me with pills and acid. They were amazing at first then eventually they just didn't work like they used to and it became a bit of a grind whenever I'd take them. Maybe I was getting worse stuff, maybe I'd developed a tolerance, maybe I just lost interest. Perhaps all three.

it's like the brain figures out it's getting tricked and stops getting tricked

 

[version]

I'm convinced England's chronically vitamin D deficient and that it accounts for a decent chunk of what's taken for the national character.

 

[luka]

seems fairly likely.

 

[version]

Maybe climate change will result in a glorious bloom of newly energised Brits.

 

[version]

Our attitude to sun's similar to our attitude to drugs and booze, actually. It comes out and everyone rushes into it and tries to get as much as they can.

 

[luka]

bi-polar country

 

[wild greens]

It's great

 

[linebaugh]

They sell 1g prerolls here in every shop and cornerstore for $10. Sometimes I buy one when I'm in a pinch—far from home, unprepared, and an occasion calls. I usually share them with a few friends and we take a few hits, only get through half of it, half to put it out, it's too much, we'd be completely zonked if we tried to finish it, even between the three of us.

the weeds changed. and not just as in the say the classic boomer adage- I think weed in the past 5 years or so has changed. I used to go through periods where I would smoke as decribed by luka and woops here and theres no way I could do that now. My wife has been recovering from surgery so weve been on the couch smoking and watching tv for a week and I still have nothing resembling a tolerance. If I hold it in and take deep breaths two hits from a joint is all I need to get sometimes dangerously high.

Ive also heard the weed situation in europe is a bit dire and we have much better stuff here

 

[WashYourHands]

Medical is legal here

Cannabis = stuff?

 

[Mr. Tea]

It turns you into a right lazy bastard if you let it

 

[WashYourHands]

isolated synthetic cannabinoids as anti-inflammatory and chemopreventive interventions

https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.12082

with breast cancer

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

Δ9-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and...

jpet.aspetjournals.org

Anandamide inhibits breast tumor-induced angiogenesis - PubMed

Breast cancer is one of the most frequently diagnosed malignancies and a leading cause of cancer death in women. Great advances in the treatment of primary tumors have led to a significant increment in the overall survival rates, however recurrence and metastatic disease, the underlying cause of...

pubmed.ncbi.nlm.nih.gov

chronic pain and inflammation

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action - PubMed

CBD and CBC stimulated descending pathways of antinociception and caused analgesia by interacting with several target proteins involved in nociceptive control. These compounds might represent useful therapeutic agents with multiple mechanisms of action.

pubmed.ncbi.nlm.nih.gov

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice - PubMed

CBC selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1.

pubmed.ncbi.nlm.nih.gov

mood but a bit too obvious

Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L - PubMed

The antidepressant action of cannabis as well as the interaction between antidepressants and the endocannabinoid system has been reported. This study was conducted to assess the antidepressant-like activity of Delta(9)-THC and other cannabinoids. Cannabinoids were initially evaluated in the...

pubmed.ncbi.nlm.nih.gov

 

[WashYourHands]

A large Australian longitudinal cohort registry demonstrates sustained safety and efficacy of oral medicinal cannabis for at least two years

Introduction Oral medicinal cannabis (MC) has been increasingly prescribed for a wide range of clinical conditions since 2016. Despite an exponential rise in prescriptions and publications, high quality clinical efficacy and safety studies are lacking. The outcomes of a large Australian clinical...

journals.plos.org

 

[WashYourHands]

Pvt UK clinic list and probably out of date, a mess of profiteering and poor supply management

 

[WashYourHands]